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AmiriFVirdisANevesMFIglarzMSeidahNGTouyzRMet alEndothelium-restricted overexpression of human endothelin-1 causes vascular remodeling and endothelial dysfunction

To compare gene and metabolite profiles between genotypes and time points, principal component analysis (PCA) and hierarchical clustering analysis were conducted using the procomp function and the ComplexHeatmap package in R (www.r-project.org)

Furthermore, supplementation with L-GSH in T2DM subjects, resulted in maintained levels of reduced GSH ( Figures 4FH ), while the group that received placebo had decreased levels of reduced GSH after 3 months ( Figures 4FH )

We confirmed that the redox imbalance caused by exogenous cystine creates a cellular environment conducive to increased gentamicin -induced bacterial mortality