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Although the exact mechanism leading to this outcome is undetermined, gene susceptibility and brain infection by several microorganisms has been associated with the pathogenesis of AD, such as for Chlamydophila pneumonie (Grard et al., Borrelia burgdorferi (Miklossy, 2011) and HSV-1 (Itzhaki, 2014, 2016), among others (Lurain et al., 2013