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The panel agreed that initial treatment should be parenteral for severe cases, while high-dose oral B12 can be considered for maintenance

Proinflammatory cytokines are also associated with altered nutrient uptake and utilization, interrupted anabolic processes, and amplified catabolic activities [55, 56]

doi: 10.1038/s41598-024-71012-2, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 325

This combination is particularly effective for individuals with genetic mutations like MTHFR that affect folate metabolism or methylation pathways FAQ How often do I need injections

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