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Additionally, irisin downregulated the downstream target protein hypoxia-inducible factor-1 (HIF-1) and upregulated peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1)

[5] Upon binding, GHRP-6 may induce a conformational change in GHS-R1a, potentially activating the phospholipase C (PLC) pathway, which may lead to the production of inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG), two secondary messengers involved in cellular signaling

For example, it is known that ferroptosis and other types of cell deaths (necroptosis and apoptosis) occur concurrently following ischemic and traumatic brain injury (Zille et al., 2017

A., Brisme, J.-M., Sizer, P

In experimental models of atherosclerosis and myocardial infarction, ALA diminishes apoptosis through the Bax/Bcl-2 and caspase signaling pathways, inhibits macrophage senescence and infiltration, promotes M2b macrophage polarization, and facilitates autophagy, thereby collectively preserving vascular integrity and myocardial functionality