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Effect of anti-human immunodeficiency virus nucleoside analogs on mitochondrial DNA and its implication for delayed toxicity

We thank the IGBMC cell culture facility, the peptide synthesis facility (Pascal Eberling), the Flow Cytometry facility (Claudine Ebel and Muriel Philipps), Molecular Biology and Virus Service (Paola Rossolillo and Nicole Jung), the Integrated Structural Biology platform (Pierre Poussin-Courmontagne), the Mediaprep facility (Denis Fumagalli)

Its this end-to-end diligence that separates good research from great research

Its pathogenesis involves tumor-like proliferation of synovial fibroblasts (FLS), local infiltration of immune cells, and the release of inflammatory cytokines that exacerbate joint inflammation and bone destruction ( Ferroptosis is a mode of iron-dependent cell death that is morphologically and biochemically distinct from apoptosis, necrosis, and pyroptosis ( The endoplasmic reticulum (ER), an important organelle in eukaryotic cells, is involved in protein synthesis, folding, structural maturation, lipid metabolism, and Ca 2+ regulation