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Key citation: Bhatt DL et al., Washington State University preclinical models demonstrating Dihexas HGF/c-Met-mediated synaptogenic activity

Eighty-three patients had RRMM that was refractory to bortezomib, carfilzomib, lenalidomide, pomalidomide, and daratumumab

Western blot analysis For protein analysis, cells or pieces of liver tissue were washed in PBS and lysed in Lysis Buffer (20 mM Tris-HCl pH8, 1 mM NaCl, 0.5% NP40, 0.5% Triton-X-100, 10% glycerol) supplemented with a protease inhibitor cocktail (SigmaAldrich)

They do, however, demonstrate this approach to be a viable strategy to be pursued as a novel oncology therapeutic avenue

A total of 343 studies met the eligibility criteria and were included in this review