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Drug Interactions Drug Interactions Affecting Co-administered Drugs: Antibiotics: Thiamine, riboflavin, pyridoxine, niacinamide and ascorbic acid decrease activities of erythromycin, kanamycin, streptomycin, doxycycline and lincomycin (7.1) Bleomycin: Ascorbic acid and riboflavin may reduce the activity of bleomycin (7.1) Levodopa: Pyridoxine may decrease blood levels of levodopa and levodopa efficacy may decrease (7.1) Phenytoin: Folic acid may decrease phenytoin blood levels and increase risk of seizure (7.1) Methotrexate: Folic acid may decrease response to methotrexate (7.1) Drug Interactions Affecting Vitamin Levels: Use In Specific Populations See 17 for PATIENT COUNSELING INFORMATION

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(48:24): And then for the blueness, those color changes, a lot of times that represents microcirculation, so the smallest blood vessels in our toes and if anybody's experienced their toes getting really cold or purplish, reddish, changing color, that can be that microcirculation

References: Almeida OP, Ford AH, Flicker L

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