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FAAX (Fentanyl Adulterated or Associated with Xylazine) was declared an emerging health threat by the US White House Office of National Drug Control Policy on April 12, 2023 (Gupta et al, 2023)

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62 Thus, consistent with the very low levels of LPO, 55,62 lysosomal ferrous iron translocated into mitochondria promotes MPTP opening and APAP-induced cell death through facilitation of protein nitration, rather than generation of LPO under normal conditions

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Targeting Signal Transduction Pathways Which Regulate Necrosis in Acetaminophen Hepatotoxicity