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The surface metal centers can be released into solution more easily when a bi- or multi- dentate ligand coordinates inside a mononuclear inner-sphere surface complex, which aids in ligand-facilitated dissolution (236)

Plots marked with three regions of ligandability changes: ligandability changes align with phosphorylation changes (region 1), ligandability changes occur without corresponding phosphorylation changes (region 2), and ligandability changes occur in the opposite direction of phosphorylation changes (region 3)

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