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The complexity of neurosteroid-mediated effects, for instance gating of GABA A R (109, 135139) and subunit-specific modulation of glycine and NMDARs (140), suggest the likelihood of multiple binding sites that contribute to potentiating and inhibitory effects ( A Rs also appears to involve modulation of subunit-containing receptors which play a role in tonic inhibition (141145)

Researchers are advised to consult all relevant literature for guidelines on the exact courses of therapy

For this page, the editorial team checks medical and regulatory claims against primary sources, clinical trials, public datasets, and regulator guidance