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Sex difference impacts on the relationship between paraoxonase-1 (PON1) and type 2 diabetes

The heart is especially susceptible to its adverse effects, primarily because these effects vary among different tissues

Zamani et al., 2020

The introduction of Cla double box mutations results in larger changes in binding affinities: Cla+Arr retrieved a K D App Ent1 2050 M (15 fold increase), while for Ent2 the decrease in its affinities is around 5 fold

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