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It displaces p53 from the FOXO4 complex, leading to nuclear exclusion of p53 and activation of the intrinsic apoptosis pathway in the senescent cell

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For antigen density experiments BSA-NIP(3), BSA-NIP(16) or BSA-NIP(80) (Norwegian Institute of Public Health) were coated at BSA concentrations of 2.5 g/mL, 0.5 g/mL and 0.1 g/mL, respectively, to obtain different surface densities with the same number of total NIP molecules

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