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Conversely, inflammatory phyla were notably expanded: Pseudomonadota (Proteobacteria) showed extreme enrichment, suggesting gut inflammation and barrier disruption, while Campylobacterota was significantly increased, consistent with pathobiont overgrowth

Furthermore, regarding the aforementioned inorganic agents their long-term non-biodegradability raises concerns about chronic toxicity and potential interference with future diagnostic imaging, necessitating rigorous longitudinal safety evaluations ( FIGURE 2 In the localized treatment of solid tumors, multi-enzyme cascade magnetic nanorobots generate reactive oxygen species (H2O2) and peroxidase-like activity via glucose oxidase (GOx) within the tumor, producing hydroxyl (OH) free radicals