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No human safety data : The complete absence of human clinical trials means the safety profile, side effects, optimal dosing, and pharmacokinetics in humans are entirely unknown Animal-to-human translation is uncertain : Metabolic differences between mice and humans mean that the magnitude of effects (e.g., weight loss, grip strength improvement) may not translate

Perspective articles allow authors to take a position on a topic of current major importance or controversy in the field of nutrition

Macrophage activation is central to PNI pathogenesis, transitioning from a proinflammatory (M1) to an anti-inflammatory (M2) phenotype with distinct functions in inflammation and repair

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Oral caps need no mixing but the published bioavailability question changes the math entirely