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With no clinically approved treatments or diagnostic markers for these conditions, there is an urgent need to define the molecular underpinnings

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Global therapeutic efficacy has been measured versus aripiprazole and dehydroaripiprazole serum concentrations, with a reported 68% response rate in those with concentrations of 150300 ng/ml of aripiprazole, and a 57 and 50% response rate with concentrations less than 150 ng/ml or above 300 ng/ml, respectively (Kirschbaum et al., 2008)

Indeed, GAPDH mutants that cannot be oxidized impair the cells ability to generate NADPH following oxidative insult [39]