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Activation of MC1R is thought to initiate cyclic AMP mediated signaling cascades that may influence transcriptional regulators such as microphthalmia associated transcription factor, which is associated with enzymes involved in eumelanin production

Interestingly, participants in this trial who were treated with 500 mg tryptophan, the amino acid precursor of melatonin, twice daily experienced similar improvements as those who received melatonin

What dermatologists actually mean by each term A freckle (ephelis) is technically a small, light brown spot caused by increased melanin production without any change in the number of melanocytes

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