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This binding leads to the release of inflammatory factors such as IL-1 and TNF, promoting macrophage polarization toward M1 pro-inflammatory phenotypes

J Biol Chem 280, 1418914202, 10.1074/jbc.M413660200 (2005)

Contrary to most other leading causes of mortality, there is no effective treatment for AD and efforts to find effective treatments have met with limited success in part because the focus has been on testing drugs that target a specific pathogenic mechanism

2025;22(6):e00722

Osteoblast stimulation and bone growth GHK-Cu increases growth of human marrow stromal cells and enhances attachment of osteoblastic cells