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Nrg4/cGAS/STING Neuregulin 4 (Nrg4), a member of the epidermal growth factor (EGF) family [104] abundantly expressed in brown adipose tissue, binds to and activates the Epidermal Growth Factor Receptor 4 (ErbB4) receptor tyrosine kinase [105], playing a critical role in various physiological and pathological processes including alleviating non-alcoholic fatty liver disease by inhibiting inflammatory factor levels, improving obesity, and optimizing lipid metabolism

Additionally, there are reports indicating that BHB may improve osteoporosis in ovariectomized rats [37]

Studies highlight the cardioprotective effects of garlic and its compounds [68, 73, 74]

A novel isoliquiritigenin loaded self-nanoemulsifying drug delivery system was developed for isoliquiritigenin and demonstrated improved bioavailability in vivo 3.92 , mainly attributed to the poor absorption, low intestinal permeability and rapid elimination of free isoliquiritigenin [116]