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doi: 10.1016/j.isci.2024.111279 128 DuanRWangTLiZJiangLYuXHeDet al

Statements Author contributions Z-GL conceived, designed, and wrote the manuscript

C.et al (2020c)

Further analyses of oxidative stress markers revealed reduced expression of superoxide dismutase, glutathione peroxidase, caspase-3 and 8-iso-prostaglandin F2

The high concentration of GSH, reaching millimolar levels (110 mM) within cells and micromolar levels (1030 M) in plasma, and its low redox potential (E 0 = 240 mV) make GSH a perfect cellular redox buffer [4,5,6]