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Depletion of intracellular glutathione contributes to JNK-mediated death receptor 5 upregulation and apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me)

The therapeutic scheme was then discussed and approved by the ethics committee of the hospital, and consent forms were signed by the family member before the therapy

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van Diemen CC, Postma DS, Aulchenko YS, Snijders PJLM, Oostra B, van Duijn CM, Boezen HM: Novel strategy to identify genetic risk factors for COPD severity: a genetic isolate