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If the country is going to move ahead with this new approach, he says, it would be helpful for the government to fund human studies of experimental peptides to generate high-quality data about whether the substances are safe and effective

Individuals who might theoretically be candidates for both treatments could include: Men with obesity and hypogonadism , where weight loss is a clinical priority alongside hormone replacement Transgender men on testosterone therapy who also have obesity-related metabolic conditions Individuals enrolled in clinical trials investigating retatrutide's effects on metabolic syndrome, where testosterone use is a pre-existing condition It is important to note that combining an unlicensed investigational drug with a licensed hormone therapy requires careful oversight

NICE recommends lifestyle modifications and PDE5 inhibitors such as sildenafil, tadalafil, vardenafil, and avanafil as first-line pharmacological treatments