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Glutathione: Pharmacological aspects Glutathione is a tripeptide (-L-glutamyl-L-cysteinylglycine) consisting of glutamate, cysteine and glycine, with an atypical peptide bond between glutamate residue and cysteine, via the -carboxyl group

O., Suchard, M

Moreover, astrocyte reactivity itself exhibits heterogeneity, meaning not all reactive astrocytes behave in the same way

For example, the nanoparticle NanoMnSor composed of a MnO 2 core and lipid and loaded PLGA with sorafenib can co-deliver sorafenib and MnO 2, where MnO 2 can reduce hypoxia by reacting with H 2 O 2 produced by overactive metabolism of tumor cells and H + in acidic TME to produce oxygen, which can not only overcome resistance to sorafenib but also promote macrophage polarization towards the immune-stimulated M1 phenotype (61)

Two studies using high throughput screening discovered active compounds with IC50 in the nanomolar range [78-79]