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Rapid rebalancing of excitation and inhibition by cortical circuitry

doi: 10.1016/j.it.2019.07.002 20 BarrebyEChenPAouadiM

In addition, these peptides are mimetic peptides targeting the extracellular loop of Cx43, which have prominent off-target effects, interfering with the channel functions of Cx32, Cx37 and Cx40 511

Future studies should focus on whether these effects are long lasting with a deeper assessment of how they may correlate clinically, given that cognition is impaired in 4070% of patients with MS ( There are limited studies evaluating cerebral glucose metabolism in relation to cognitive impairment in MS patients