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Studies of stored RBCs in blood bank conditions also reported the recruitment of Prx2, CAT and GPx to the RBC membrane due to OS modifications resulting from the metabolic stress of long-term erythrocyte storage [93, 97]

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6 illustrates the various redox-sensitive signaling pathways and their role in antioxidant gene expression in response to exercise, inflammation, growth factors, infection, stress and ischemia-reperfusion (I-R)