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As potential inducer of HEP expression, phytoestrogens are promising dietary supplements to reduce iron overload and prevent any sequelae of iron-induced toxicities such as hyperferritinemia, coagulopathies and/or thromboembolism, which are prominent clinical manifestations in COVID-19 and PASC 94,144,494,495

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Ongoing research into GPx4s role continues to uncover its implications in cancer therapy, where promoting ferroptosis could eliminate tumor cells resistant to traditional apoptosis inducers

[14] In addition, electrons from the succinate oxidation step are transferred first to the FAD cofactor of succinate dehydrogenase, reducing it to FADH 2 , and eventually to ubiquinone (Q) in the mitochondrial membrane, reducing it to ubiquinol (QH 2 ) which is a substrate of the electron transfer chain at the level of Complex III