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In a randomized, double-blind study, older patients with frailty who showed changes in their gut microbiota demonstrated improved gut microbiota and muscle strength after taking prebiotics (Ni Lochlainn et al

doi: 10.1089/omi.2011.0118 30 HnzelmannSCasteloRGuinneyJ

The potential mechanisms by which SASP contributes to LOMG pathophysiology include: (1) Priming effect: senescent cells accumulated within the CNS create a chronic pro-inflammatory microenvironment through SASP, lowering the response threshold of brain parenchyma to peripheral immune signals

10.2174/1874091X01004010077 Open Biochem J

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