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80,81 Similarly, NF-B activation in rats by intra-articular transfer of an adenoviral vector encoding IKK induces synovial inflammation and clinical signs of arthritis, whereas intra-articular transfer of a dominant-negative IKK mutant suppresses adjuvant-induced arthritis

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A limitation of this study is that all CLN3 patientderived replicates originate from a single individual

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