pt141 libido study Double-blind, placebo-controlled evaluation of the safety, pharmacokinetic properties and pharmacodynamic effects of intranasal PT-141, a melanocortin receptor agonist, in healthy males and patients with mild-to-moderate erectile dysfunction PT-141 Bremelanotide Nasal Spray –

Abbreviations A:G: Albumin:globulin ratio AChE: Acetylcholinesterase ACP: Acid phosphatase AFB 1 : Aflatoxin B1 AFL: Aflatoxicol AFM 1 : Aflatoxin M1 AFQ 1 : Aflatoxin Q1 AFs: Aflatoxins ALP: Alkaline phosphatase ALT: Alanine aminotransferase AME: Alternariol monomethyl ether Ampk: SIRT1/5-AMP-activated protein kinase AMPs: Antimicrobial peptides AOH: Alternariol Apaf-1: Apoptotic protease activating factor-1 ASI: Adipose somatic index AST: Aspartate aminotransferase Bax: Bcl2-associated X protein BEA: Beauvericin C3: Complement 3 protein C4: Complement 4 protein CAT: Catalase CP: Crude protein CYP450: Cytochrome P450 DON: Deoxynivalenol DON-3Glc: Deoxynivalenol-3-glucoside ENA 1 : Enniatin A1 ENB 1 : Enniatin B1 ERE: Energy retention efficiency EROD: 7-Ethoxy-resorufin-O-deethylase ERs: Estrogen receptors FasL: Fas ligand FB 1 : Fumonisin B1 FB 2 : Fumonisin B2 FBW: Final body weight FCR: Feed conversion ratio FI: Feed intake FUMs: Fumonisins GSH: Glutathione GSH-Px: Glutathione peroxidase GSI: Gonadosomatic index GST: Glutathione S-transferase Hb: Hemoglobin Hpf: Hours post fertilization HSI: Hepatosomatic index Ht: Hematocrit HT2-3Glc: HT-2-toxin-3-glucoside IFN1: Type-I interferon IFN: Interferon IgM: Immunoglobulin M IL: Interleukin IL-1: Interleukin 1 inf-: Interferon INF-2: Interferon 2 IRF3: Interferon regulatory factor 3 JNK: C-Jun N-terminal protein kinase keap1: Kelch-like ECH-associated protein 1 LDH: Lactate dehydrogenase LEAP: Liver expressed antimicrobial peptide Lfabp: Liver fatty acid binding protein LOD: Limit of detection LOQ: Limit of quantification LZ: Lysozyme MAPKs: Mitogen-activated protein kinases MCH: Mean corpuscular hemoglobin MCHC: Mean corpuscular hemoglobin concentration MCV: Mean corpuscular volume MDA: Malondialdehyde MLCK: Myosin light chain kinase ND: Non-detected NIV-3Glc: Nivalenol-3-glucoside NM: Non-mentioned NRE: Nitrogen retention efficiency Nrf2: Nuclear factor erythroid 2-related factor 2 NTB: Nitroblue tetrazolium assay OTA: Ochratoxin A PAPs: Processed animal proteins PC: Protein carbonyl PL: Phospholipids ppar-: Peroxisome proliferator-activated receptor RBCs: Red blood cells RE: Recovered energy RF: Relative brood amount RN: Retained nitrogen ROS: Reactive oxygen species SF: Spawning frequency SGR: Specific growth rate SOD: Superoxide dismutase srebp1: Sterol responsive element binding protein 1 SULT: Sulfotransferase T-2: Toxin T-2 T-2-3Glc: T-2-toxin-3-glucoside TAOC: Total antioxidant capacity TGC: Thermal unit growth coefficient TGs: Triglycerides TJs: Tight junctions TNF-: Tumour necrosis factor TP: Total protein TW: Total weight UGT: Glucuronosyltransferase Vtg: Vitellogenin WBC: White blood cells WG: Weight gain ZEN: Zearalenone ZEN-4Glc: Zearalenone 4-glucoside -ZEL: -Zearalenol -ZEL-14Glc: -Zearalenol-14-glucoside -ZEL: -Zearalenol -ZEL-14Glc: -Zearalenol-14-glucoside References Abdallah MF, Girgin G, Baydar T, Krska R, Sulyok M (2017) Occurrence of multiple mycotoxins and other fungal metabolites in animal feed and maize samples from Egypt using LC-MS/MS

Useful probe for the entire melanocortin receptor family

Radzeviius A

2025;51:e5e9

Benefits Rapid Itch Relief: Quickly reduces the urge to scratch, protecting the skin from further irritation