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& Lapresle, C

1 H NMR (400 MHz, DMSO-d6) = 10.49 (s, 1H), 8.67 (dd, J = 5.2, 1.8 Hz, 1H), 8.00 (td, J = 7.7, 1.9 Hz, 1H), 7.92 7.83 (m, 2H), 7.66 (d, J = 8.1 Hz, 1H), 7.51 (ddd, J = 7.3, 4.8, 1.1 Hz, 1H), 7.06 6.89 (m, 2H)

10 Since discoloration becomes visible only when the extravasated blood is located close to the skin surface, 9 the depth of injection can be considered a critical factor

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Guarana ( Paullinia cupana ) is an Amazonian plant that contains catechins, epicatechins, and a small amount of caffeine (Subbiah 2008)