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A series of investigative studies were conducted in dogs to determine the optimal absorption window for hydrocortisone, enabled by multi-particulate formulations with a significantly shortened sustained-release phase such that the majority of the drug payload would be released in the small intestine

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According to NICE guidelines, OCA may be recommended for specific cases of cartilage damage in the knee: Lesion Size : Defects larger than 2 cm, where the lesion involves both cartilage and subchondral bone