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Plasma concentrations reach peak levels within 30 to 60 minutes

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This maximal urine osmolarity constitutes a limit above which the two functions of kidneys cannot coexist anymore: it defines a minimal obligatory volume strictly necessary to excrete the solute load, whatever the body water balance status

However, subcutaneous injection is the standard route for systemic and musculoskeletal effects, as it provides more reliable bioavailability and allows injection near the injury site

It also i nteracts with multiple biologi cal pathways, providing cytoprotective, neuroprotective, and anti-inflammatory effects