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BMC Biotechnol 4:32 Acknowledgments The authors would like to thank Huira Chong and Jennifer Aurandt for critical review of the manuscript

Research indicates that NNMT expression correlates positively with insulin resistance, with plasma levels of the NNMT product 1-methylnicotinamide associated with increased body mass index and metabolic dysfunction

Although AC has demonstrated promising pharmacological activities in a wide range of in vitro and in vivo models, its clinical evaluation remains relatively limited

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Also, an extension from stomach epithelium protection to stomach endothelium protection (and thereby concept background stomach endothelium stomach epithelium protection) (21-24) permits cytoprotective agents as an endothelium protectants class (although this was not originally claimed) (21-24), and consequently, application in thrombosis and bleeding disorders (5, 8, 25-28)