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Anti-tumor immune cells, such as T cells, can induce tumor cells to undergo pyroptosis while simultaneously increasing ROS to trigger ferroptosis, thereby exerting anti-tumor effects (198, 199)

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Clinically, mitochondrial dysfunction symptoms include: dysautonomia (orthostasis, heat intolerance, POTS-like symptoms) muscle rigidity or tremors variable energy levels cognitive fog heightened reactivity to stress worsening symptoms during infection or inflammation poor exercise tolerance These same patterns appear in Parkinsons disease, neurodegenerative disorders, dysautonomia, and trauma-linked hyperarousal

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doi: 10.3389/fendo.2020.601290 Received 31 August 2020 Accepted 12 November 2020 Published 14 December 2020 Volume 11 - 2020 Edited by Magdalene K