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In the context of cancer, high dietary zinc intake has been shown to promote tumor progression by fostering a pro-tumorigenic environment mediated by T cells

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(2) Construction of a cross-organ core mechanism network, transcending the limitations of single-organ focus, to uncover shared core mechanisms spanning the lungs, kidneys, heart, liver, and brain (e.g., the NF-B/NLRP3 inflammatory axis, the Nrf2/HO-1 antioxidant system, the AMPK/mTOR immunometabolic axis), thereby untangling the molecular principles by which natural products regulate systemic homeostasis