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Branching morphogenesis assay RPTEC (2 10 4 cells) were suspended in 400 l Cellmatrix type IA collagen solution (Nitta Gelatin) in a 48-well plate and allowed to gel for 60 min at 37 C, according to the manufacturers instructions

The BBB here thus play an even more important role as it is necessary to find treatment options that can cross the BBB and reach the brain

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[0350] Various delivery systems are known and can be used to administer the pharmaceutical compositions described herein, e.g., encapsulation in liposomes, microparticles, microcapsules, recombinant cells capable of expressing the mutant viruses, receptor mediated endocytosis (see, e.g., Wu et al., 1987, J

Thus, CDs are promising drug delivery platforms for CNS diseases and disorders