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2.2 The regulatory mechanism of metformin on endometrial receptivity A good endometrium allows the blastocyst to attach, penetrate, and induce local decidualization of interstitial cells, thus providing an ideal environment for implantation of the fertilized egg and offering support for the growth of the embryo

** (2006) Endogenous phosphatidylcholine and a long spacer ligand stabilize the lipid-binding groove of CD1b

Roadmap for therapy development Five critical areas were identified for SSMD: the disease, the target, drug candidates (repurposing and new), testing and lead identification, and clinical trials and compassionate use

Core metabolic testing may establish a baseline, while additional tests should be selected according to symptoms and risk

Biochim Biophys Acta Mol Cell Biol Lipids 1863(3):235246