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Ototoxicity resulting from cytostatic agents is often dose-dependent and may be exacerbated by concurrent administration of other ototoxic medications (Patatt et al

In a clinical trial designed to evaluate the effects of apple extract (AP) supplements containing PCs on skin pigmentation issues induced by UV exposure in healthy women, participants were randomly assigned to three groups: a low-dose AP group (300 mg/day), a high-dose AP group (600 mg/day), and a placebo group

In such cases, the remaining amount of nitric oxide after its reaction with the test sample is quantified as nitrite

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At the 4-h time point, serum levels of alanine transaminase and aspartate transaminase (AST) were markedly higher in the hepsin / mice, indicating more severe liver damage compared with their wild-type counterparts (Fig