glutathione nadph assay Pitfalls in the analysis of the physiological antioxidant (GSH) and its disulfide (GSSG) in biological samples: An elephant in the room Recovery of GSSG from a

Metabolic flexibility Although glutamine is the primary carbon source for the TCA cycle in some cancer cells, replenishment of TCA cycle intermediates using alternative anaplerotic substrates reduces bioenergetic stress, thereby enabling resistance to inhibition of glutamine metabolism

doi: 10.1038/ni.1831 70 AarrebergLDEsser-NobisKDriscollCShuvarikovARobyJAGale JrM

This complex mixture contains at least 18 active components, including active peptides, enzymes, amino acids, proteins, phospholipids, sugars, and other non-peptide elements ( Table 1 ) (54, 55)

Interestingly, USP24 knockdown had little impact on DHODH gene expression levels in either cell line (Supplementary Fig

Protein methylation in the regulation of ferroptosis