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Peer review Peer review information Nature Reviews Molecular Cell Biology thanks Charles Brenner, Evandro Fang and Lindsay Wu for their contribution to the peer review of this work

Notably, HIF-1 mediates adaptive metabolic responses to hypoxia by enhancing glycolytic pathway, serine synthesis and one-carbon metabolism to promote mitochondrial antioxidant production (NADPH and GSH), and inhibiting the TCA cycle so as to diminish mitochondrial ROS production (247)