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Its analgesic effects were comparable to that of morphine, but notably, LPF-35 did not induce tolerance or dependence, suggesting a non-opioid mechanism of actionpossibly through local anti-inflammatory effects and modulation of nociceptive signaling at nerve endings and ion channels

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People who use Zepbound or Mounjaro, the dual-agonist medications, lose an average of about 20% of their body weight, while those who take Ozempic or Wegovy, the single-agonist drugs, lost an average of about 14% of their body weight

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Psychiatry, 13 , 611616