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The autophagosome is subsequently fused with the lysosome to allow degradation of the sequestered material (Fig

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3.5 GHK-Cu regulated the SIRT1/STAT3 pathway SIRT1, which is closely associated with cellular metabolism and stress responses, also interacts with the STAT3 pathway (Figures 6AD, DSS-induced mice exhibited significantly increased SIRT1 expression and decreased p-STAT3 expression compared to the Control group

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It acts on both GLP-1 and GIP receptors and has become a central reference compound in metabolic research, especially in models of appetite regulation, body-weight change, glycaemic control and incretin signalling