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For instance, NOX1 and NOX2 are critical for the differentiation of monocytes to macrophages and the M2-type polarization, as assessed in macrophages from NOX1/NOX2 double knockout mice ( Nox2 -deficient mice were protected against hepatic steatosis induced by high-fat diet and insulin resistance ( Finally, different studies investigated the impact of NOX in the activation of the NLRP3 inflammasome in macrophages

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Further research showed that L-theanine had a potential preventive effect on neointimal hyperplasia and related vascular remodeling, mainly by inhibiting the phosphorylation of Elk-1 and activating mitogen-activated protein kinase-1 (MAPK-1) (84)