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Emerging therapeutic approaches to target the dark side of senescent cells: new hopes to treat aging as a disease and to delay age-related pathologies

Additionally, the rs2043211 variant of CARD8 and the G allele of IL1B rs1143623 have been linked to gout, with an epistatic interaction between these variants suggesting a mechanism involving increased NLRP3 inflammasome activity and IL-1 production in response to MSU crystals

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Special thanks to Beth Mahler and Emily Singletary for photography support