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Heffernan 2001a Mouse studies using chronic osmotic pump delivery showed AOD-9604 increased fat oxidation and plasma glycerol (a lipolysis marker) to a degree comparable with full-length hGH, without inducing hyperglycaemia or reducing insulin secretion

D-Nle-Tyr-Ile-NH-(CH 2 ) 5 - CONH 2 appeared to be extensively distributed outside the central blood compartment and/or bound within the tissues as evidenced by its large volume of distribution (Vd)

To overcome these challenges, future studies should focus on developing advanced imaging techniques, such as MRI, to track the real time biodistribution of MNPs (Remmo et al., 2024)

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Adding AOD-9604 might bring that total to 7-8.5 kg, with the additional loss coming predominantly from fat tissue rather than lean mass