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For collagen-specific support, GHK-Cu can be added at systemic doses via subcutaneous administration or applied topically over affected areas

Diagnostic evaluation Recommendations and suggestions R5.1 We recommend an andrological consultation in case of symptoms and signs of epididymo-orchitis to confirm the clinical diagnosis (1, )

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Therapeutic opportunities and challenges Genetic screens carried out so far in GBM have enabled the identification of genes driving metabolism, growth and cell cycle, DNA-repair and immortality pathways