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Graphical Abstract The graphical abstract depicts an overview of the pathways involved in the emergence of morphine-related tolerance and dependence including NMDA, Nitric oxide, and PPAR, as well as behavioural sensitization along with present and future innovative treatment strategies including stem cell therapy that have been discussed in the current manuscript

Conclusions: The results from this study indicated that the admini- stration of a pantothenic based dietary supplement in healthy human adults with mild to moderate acne vulgaris is feasi- ble, safe and well tolerated