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One trial suggests it may help reduce weight in overweight people with diabetes when used as an add on to the anti-obesity drug orlistat [2]

In the past, some physicians continually prescribed opioids to their patients to treat their pain

Human hepatoma cells (HepG2) are widely used as an in vitro model to study the effects of several xenobiotics in hepatocytes [37, 38]

More significantly, MOTS-c administration shifted the trajectory of age-related metabolic decline, indicating that the peptide's benefits are not limited to preventing dysfunction in young animals but can partially reverse established decline [2]

First hints towards this idea came from genome-wide association studies mapping IBD genetic risk loci to mitochondrial function-associated genes 26,27,28 , implying mitochondrial disturbances as underlying mechanism in IBD pathogenesis