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The metabolic state in PD effluent could tell how healthy the membrane is and how long it will survive

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Markers of lipid and DNA oxidative damage have been detected in several CNS cells, including neurons, axons, myelin, and OLs in early active lesions with the highest levels of expression in cells that morphologically resembled apoptotic OLs [10,11]

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L.MoranG

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The FAM171A2 gene is a key regulator of progranulin expression and modifies the risk of multiple neurodegenerative diseases

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Moreover, it was unclear at the time which cellular phenotypes correspond to either primary or secondary effects due to the lack of FXN

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