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Questions that researchers are still working on include: How much of an oral dose actually gets absorbed into the bloodstream after digestion

Although vitamin B12 is water-soluble and excess amounts are typically excreted in the urine, the body still stores significant quantities (primarily in the liver) with its levels continuously regulated

Analytical size-exclusion chromatograms and corresponding SDSPAGE analyses are shown in Extended Data Fig

10.1136/gut.32.11.1261 Gut 142 ReinerA.LevitzJ

I would also be interested to know what the binding affinities are for NET monomers versus the mostly oligomers here and if there's concentration-dependence to this binding, if this is physiologically relevant, etc