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The CYP450 enzyme CYP1A2 plays a crucial role in the primary metabolism of aromatic amine carcinogens, and its polymorphisms have been linked to genetic susceptibility to bladder cancer (Pavanello et al., 2010)

Elevated kynurenine levels are remarkably associated with insulin resistance and -cell dysfunction, potentially contributing to the pathogenesis of diabetes through mechanisms involving inflammatory responses and oxidative stress, influencing the pathological progression of CHD (77)

Close to the pI, solubility decreases, and proteins carry minimal net charge, leading to reduced electrostatic repulsion and weak interfacial films, which promote droplet coalescence and destabilization (Albano et al., 2019)

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